Sequential calculation of torque in procedure of twin screw extrusion

The drug making resreach has accentuated on extrusion technology for a long time. The advance of drug bioavailibility, bead manufacturing and granulation is assured by extrusion procedures. There are also diverse effects in resereches with respect to the use of process understanging as a tool in quality management. Many initiatives of FDA such as PAT and QBD are getting accepted. In this survey a corotating twin-screw extruder was facilitated with a torque gauge as a tool to monitor the process. The experimental arrangements were qualified based on the ICH instructions. The extrusion torque has a relation with the water content in a wet extrusion process. Besides, a process of pelletisation was done utilizing various formulations in wet spheronization. There found the relationship between the torque on the screws and the form of the pellet. In a nutshell, the torque proved to be a very good extrusion criteria for monitoring processes of wet extrusion